arthritis: An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1376 |
4. Check minimum number of eventsNone |
1376 |
5. Include endpointsNone |
1376 |
6. Filter based on genotype QC (FinnGen only) |
1376 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Arthropathies in other diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7953 | 4329 | 3586 |
| Only index persons | 7376 | 4059 | 3317 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.10 |
| Only index persons | 0.14 | 0.15 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 57.35 | 57.57 | 57.00 |
| Only index persons | 56.79 | 56.82 | 56.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1376 | 741 | 635 |
| Unadjusted period prevalence (%) | 0.27 | 0.25 | 0.28 |
| Median age at first event (years) | 55.17 | 52.75 | 57.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1255
- Matched controls
- 12548
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHINOTH | 2.188 [1.92, 2.49] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 1169 out of 4053 females with M13_ARTHINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHINOTH | 2.67 [2.33, 3.06] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 1086 out of 3233 males with M13_ARTHINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.58% |
| 5 | 1.151% | 3.633% |
| 10 | 2.664% | 8.154% |
| 15 | 5.292% | 14.826% |
| 20 | 9.235% | 24.39% |
Relationships between endpoints
↥Index endpoint: M13_ARTHINOTH – Arthropathies in other diseases classified elsewhere
GWS hits: 1