gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
37318 |
4. Check minimum number of eventsNone |
37318 |
5. Include endpointsNone |
37318 |
6. Filter based on genotype QC (FinnGen only) |
37318 |
Control definitions (FinnGen only)
- Control exclude
- K11_OESSTODUO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K20-K31
- Name in latin
- Morbus refluxualis gastro-oesophageus
Similar endpoints
↥List of similar endpoints to
Gastro-oesophageal reflux disease
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 244622 | 129853 | 113501 |
Only index persons | 222545 | 121042 | 101503 |
Unadjusted period prevalence (%) | |||
Whole population | 3.45 | 3.72 | 3.17 |
Only index persons | 4.19 | 4.45 | 3.87 |
Median age at first event (years) | |||
Whole population | 54.59 | 56.28 | 52.67 |
Only index persons | 54.66 | 56.25 | 52.76 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 37318 | 21875 | 15443 |
Unadjusted period prevalence (%) | 7.19 | 7.46 | 6.81 |
Median age at first event (years) | 56.33 | 55.36 | 57.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 33529
- Matched controls
- 297833
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint K11_REFLUX and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
K11_REFLUX | 1.086 [1.0, 1.18] | 0.045 |
Birth year | 0.994 [0.99, 1.0] | 0.196 |
During the follow-up period (1.1.1998 — 31.12.2019), 15214 out of 108719 females with K11_REFLUX died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
K11_REFLUX | 1.289 [1.19, 1.4] | < 0.001 |
Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 18165 out of 94271 males with K11_REFLUX died.
Mortality risk
Mortality risk for people of age
years, who have K11_REFLUX.N-year risk | Females | Males |
---|---|---|
1 | 0.114% | 0.243% |
5 | 0.634% | 1.493% |
10 | 1.6% | 3.681% |
15 | 2.999% | 6.704% |
20 | 5.296% | 11.685% |
Relationships between endpoints
↥Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits: 2