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Unspecified protein-energy malnutrition

DOID EFO Endpoint Browser PheWeb

E4_PROTMALNAS

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E46
  • Hospital discharge: ICD-9 — 263[8-9]
  • Hospital discharge: ICD-8 — 26799
  • Cause of death: ICD-10 — E46
  • Cause of death: ICD-9 — 263[8-9]
  • Cause of death: ICD-8 — 26799

2 out of 7 registries used, show all original rules.

181

4. Check minimum number of events

None

181

5. Include endpoints

None

181

6. Filter based on genotype QC (FinnGen only)

181

Control definitions (FinnGen only)

Control exclude
E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio non specificata ex deficientia proteino-energetica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2837 1661 1166
Only index persons 2520 1510 1010
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 75.04 77.51 71.59
Only index persons 75.85 78.14 72.43

-FinnGen-

Key figures

All Female Male
Number of individuals 181 102 79
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 72.89 69.94 76.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
160
Matched controls
1598
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E46
ICD-10 Finland
Unspecified protein-energy malnutrition
+∞
214.9
154
*
E86
ICD-10 Finland
Volume depletion
14.5
16.6
28
23
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.3
11.5
80
369
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
10.4
11.4
22
24
R63.4
ICD-10 Finland
Abnormal weight loss
10.8
11.1
21
22
N05AX08
ATC
risperidone; systemic
5.9
11.1
32
65
A28
ICPC
Limited function/disability NOS
3.8
10.8
55
195
E87.6
ICD-10 Finland
Hypokalaemia
10.5
9.5
18
19
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.7
8.6
18
23
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.3
8.5
47
178
R4110
NOMESCO Finland
Physiotherapy
2.9
8.3
59
264
L28
ICPC
Limited function/disability (L)
3.2
8.1
48
190
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.4
7.8
18
27
R53
ICD-10 Finland
Malaise and fatigue
2.9
7.5
55
245
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.8
7.5
18
29
D64.9
ICD-10 Finland
Anaemia, unspecified
3.7
7.3
33
106
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
7.2
60
291
C03CA01
ATC
furosemide; systemic
2.5
7.0
75
418
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.4
6.9
20
41
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.9
6.9
45
188
I95.1
ICD-10 Finland
Orthostatic hypotension
6.0
6.8
18
33
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
6.8
27
77
F03
ICD-10 Finland
Unspecified dementia
5.0
6.8
21
47
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
6.7
34
119
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
6.7
63
323
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
6.4
43
182
SPAT1229
SPAT
Assessment of need for aid
3.6
6.4
29
93
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
6.4
43
183
W19
ICD-10 Finland
Unspecified fall
3.6
6.3
28
89
N02AA05
ATC
oxycodone; systemic
3.0
6.2
38
151
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.4
6.1
21
53

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
191
4.75
21.10
3.3
2.4
18.08
22.92
%
1.54
58
161
80
290
4.15
19.41
2.4
1.8
1309.50
1116.22
nmol/l
1.17
61
212
48
122
4.99
18.41
3.4
2.2
71.77
64.38
e9/l
0.79
40
95
92
385
3.83
17.83
2.7
2.3
3.61
3.09
mg/l
0.53
84
326
132
729
3.99
16.26
9.9
7.2
1.20
1.22
mmol/l
2.00
110
612
125
667
3.83
16.21
7.0
6.7
1.20
1.22
mmol/l
2.00
118
597
114
575
3.65
16.11
3.6
2.6
72.65
78.92
nmol/l
1.32
108
501
56
179
4.08
15.79
2.7
2.4
2.02
1.70
%
1.31
51
154
110
577
3.31
13.92
2.8
2.0
79.27
96.81
pmol/l
3.31
66
275
89
413
3.27
13.85
6.0
4.3
—
—
—
0
0
75
316
3.35
13.68
5.2
2.9
528.40
534.73
mosm/kgh2o
0.09
68
266
78
368
2.97
11.31
5.7
3.8
—
—
—
0
0
35
100
4.10
11.26
1.7
2.2
—
—
—
0
0
52
195
3.34
11.19
2.8
2.3
—
—
—
0
0
102
563
2.86
10.93
3.7
2.8
203.37
113.07
ug/l
1.87
94
505
97
524
2.83
10.80
8.4
4.2
108.09
89.69
e6/l
0.16
79
377
94
500
2.83
10.77
4.2
3.1
2.30
2.36
mmol/l
2.08
87
432
79
387
2.85
10.54
7.3
4.3
—
—
—
0
0
45
160
3.41
10.49
2.1
1.8
—
—
—
0
0
89
471
2.75
10.15
5.3
3.4
513.02
189.03
e6/l
0.32
77
360
19
36
5.78
9.87
1.4
1.4
221.75
290.95
ug/g
0.72
12
22
13
16
8.68
9.86
2.5
1.7
32.69
31.81
pg
0.17
13
16
81
423
2.66
9.30
3.4
2.5
—
—
—
0
0
75
378
2.68
9.24
5.7
4.6
0.00
0.00
estimate
0.00
25
122
54
230
2.92
9.17
5.8
3.2
6.47
3.03
e6/l
1.24
45
124
88
486
2.58
8.92
5.8
3.5
—
—
—
0
0
96
553
2.57
8.89
6.5
4.3
49.15
44.65
ng/l
0.12
85
396
16
29
5.96
8.66
1.2
3.9
—
—
—
0
0
84
459
2.55
8.64
8.9
5.2
—
—
—
0
0
109
675
2.55
8.54
7.5
5.7
0.00
0.00
estimate
0.00
27
124
35
123
3.29
8.20
3.3
3.6
100.93
71.11
ng/l
0.67
29
108
108
678
2.47
8.05
5.8
4.3
0.00
0.00
estimate
0.00
25
120
107
674
2.44
7.84
5.4
4.2
0.00
0.00
estimate
0.00
25
132
37
140
3.06
7.64
2.9
6.3
1.45
1.35
mmol/l
0.24
27
129
19
46
4.50
7.48
5.1
4.1
—
—
—
0
0
29
96
3.41
7.44
3.8
4.3
0.00
0.31
%
—
9
26
77
427
2.40
7.42
3.6
2.2
243.13
233.98
u/l
0.04
71
403
30
102
3.33
7.38
3.7
4.2
0.09
0.16
%
0.24
11
31
102
644
2.34
7.24
9.1
5.6
8.40
8.69
%
0.37
96
602
11
16
7.26
7.23
1.9
1.2
274.09
271.10
mosm/kgh2o
—
11
10
101
639
2.31
7.08
8.9
5.3
2.22
2.84
%
2.02
96
595
30
108
3.13
6.71
3.9
4.1
0.45
0.94
%
0.78
11
35
38
157
2.80
6.67
5.7
4.4
—
—
—
0
0
60
312
2.38
6.55
1.9
1.9
462.60
471.71
pmol/l
0.07
42
255
104
681
2.24
6.53
9.1
5.2
0.03
0.04
e9/l
0.70
98
590
106
700
2.24
6.51
9.1
5.4
0.16
0.19
e9/l
0.85
99
613
98
628
2.22
6.47
9.1
5.3
0.51
0.66
%
2.06
92
583
37
153
2.78
6.47
5.8
3.8
1.77
2.08
mmol/l
0.14
30
114
102
665
2.22
6.45
9.5
5.4
21.36
28.11
%
6.82
94
615
66
361
2.30
6.40
2.2
1.6
20.93
22.11
nmol/l
0.19
59
300
41
180
2.65
6.39
1.4
1.3
—
—
—
0
0
17
43
4.26
6.32
1.2
3.3
55.03
87.85
mg/l
0.37
12
33
17
43
4.26
6.32
1.2
3.4
57.09
26.44
mg/l
0.65
12
33
54
272
2.40
6.30
6.5
4.7
—
—
—
0
0
100
653
2.19
6.22
8.6
5.2
62.37
56.72
%
3.46
93
609
133
978
2.36
6.12
5.5
4.1
17.75
12.73
mm/h
2.49
128
879
41
184
2.59
6.10
5.5
7.0
102.34
104.22
mmol/l
1.50
41
179
104
698
2.15
5.94
9.0
5.2
1.49
1.88
e9/l
3.31
96
617
102
680
2.15
5.92
9.2
5.2
0.61
0.57
e9/l
0.75
97
587
23
77
3.28
5.77
4.7
5.7
—
—
—
0
0
88
562
2.10
5.63
16.9
8.5
1.30
1.25
inr
0.21
35
162
18
55
3.52
5.18
1.1
1.2
—
—
—
0
0
73
448
2.05
5.08
5.7
3.7
7.40
7.40
ph
0.17
23
78
111
794
2.03
5.00
16.4
8.5
4.79
4.07
e9/l
2.09
106
685
13
32
4.30
4.99
1.2
1.4
—
—
—
0
0
13
32
4.30
4.99
4.5
2.9
2.41
2.32
mmol/l
—
7
19
24
90
2.92
4.98
1.3
1.3
—
—
—
0
0
56
313
2.14
4.97
4.8
4.8
1.01
1.01
kg/l
—
7
48
24
91
2.89
4.88
3.8
4.3
0.50
0.75
%
—
8
20
10
20
5.23
4.83
4.6
2.5
4.46
4.96
e9/l
—
10
20
53
293
2.14
4.83
4.3
3.1
2.48
2.46
mmol/l
0.55
48
248
124
937
2.03
4.62
5.8
4.6
—
—
—
0
0
10
21
4.98
4.59
5.7
2.6
62.00
60.00
%
—
10
21
11
26
4.44
4.42
1.1
1.5
—
—
—
0
0
12
31
4.07
4.33
3.6
2.8
0.79
0.69
nmol/l
—
7
22
126
970
1.98
4.30
4.7
3.9
15.20
15.05
pmol/l
0.22
119
853
49
275
2.07
4.24
1.8
1.5
2.96
2.47
g/l
0.78
37
154
87
609
1.83
3.83
20.3
9.7
0.00
0.02
e9/l
0.45
81
491
27
124
2.38
3.77
1.7
1.4
—
—
—
0
0
9
16
5.86
3.71
1.1
1.0
—
—
—
0
0
9
16
5.86
3.71
1.2
1.8
—
—
—
0
0
12
36
3.50
3.54
4.1
2.7
—
—
—
0
0
6
6
10.28
3.52
19.7
15.7
1002.83
1530.17
nmol/l
—
6
6
6
6
10.28
3.52
17.3
12.5
804.67
795.17
nmol/l
—
6
6
24
108
2.41
3.50
7.1
3.9
—
—
—
0
0
15
53
3.00
3.45
1.9
3.5
0.18
0.40
g/l
—
7
21
142
1179
1.95
3.38
5.8
4.7
2.06
1.96
mu/l
0.29
136
1043
6
7
8.81
3.28
2.0
1.6
27.50
30.29
umol/l
—
6
7
154
1320
2.12
3.28
39.4
16.2
30.69
24.83
mg/l
1.15
143
1053
10
29
3.59
3.09
1.1
1.3
—
—
—
0
0
6
8
7.71
3.08
1.2
1.1
—
—
—
0
0
12
40
3.14
3.03
1.2
1.3
1.20
1.13
g/l
0.47
12
40
12
40
3.14
3.03
1.2
1.3
0.23
0.22
g/l
0.07
12
40
55
357
1.78
2.98
10.0
7.1
—
—
—
0
0
11
36
3.19
2.86
2.7
2.5
16.52
15.25
%
—
6
19
8
18
4.60
2.83
1.3
1.6
—
—
—
0
0
12
42
2.99
2.81
1.4
1.7
—
—
—
0
0
14
54
2.73
2.77
4.4
13.8
0.72
0.96
%
1.15
14
49
6
10
6.16
2.72
1.8
1.4
—
—
—
0
0
8
19
4.35
2.71
1.1
1.4
—
—
—
0
0
48
308
1.76
2.68
2.8
2.8
340.91
1972.38
umol/l
0.80
43
252
7
15
4.81
2.62
1.0
1.0
—
—
—
0
0
5
7
7.30
2.56
2.0
1.0
—
—
—
0
0
48
313
1.73
2.53
1.4
1.3
—
—
—
0
0
60
417
1.66
2.49
4.3
3.2
0.77
0.42
e6/l
0.50
50
312
58
400
1.66
2.48
4.4
3.1
—
—
—
0
0
21
104
2.15
2.48
3.1
8.4
—
—
—
0
0
32
186
1.88
2.45
2.0
1.8
—
—
—
0
0
30
172
1.89
2.39
2.9
9.3
2.04
1.43
mmol/l
0.27
21
128
24
128
2.01
2.35
5.8
7.3
—
—
—
0
0
23
121
2.03
2.33
2.0
1.4
—
—
—
0
0
13
54
2.52
2.25
4.6
13.7
1.27
1.64
%
1.14
13
49
110
901
1.56
2.22
5.9
4.1
—
—
—
0
0
152
1349
1.79
2.19
40.2
14.5
—
—
—
0
0
12
49
2.55
2.15
2.4
2.2
—
—
—
0
0
29
171
1.83
2.13
2.9
9.4
10.96
11.37
kpa
0.18
29
161
29
171
1.83
2.13
2.9
9.4
5.07
5.05
kpa
0.03
29
161
26
148
1.88
2.12
1.8
1.5
—
—
—
0
0
47
320
1.63
2.08
1.4
1.3
0.81
1.02
u/ml
0.30
19
86
5
10
5.11
2.08
1.4
1.1
—
—
—
0
0
7
21
3.42
1.98
1.1
1.5
—
—
—
0
0
5
11
4.64
1.95
2.6
1.4
3.54
4.52
nmol/l
—
5
11
5
11
4.64
1.95
1.2
1.2
—
—
—
0
0
22
125
1.87
1.82
3.5
2.0
43.27
31.03
u/l
0.52
22
102
11
47
2.43
1.81
9.8
6.1
1.55
1.52
mg/l
0.05
11
39
42
290
1.58
1.75
5.5
3.7
87.29
278.02
ng/l
1.28
31
237
47
335
1.54
1.70
3.4
2.7
4.72
5.37
e6/l
0.17
39
297
134
1182
1.51
1.65
5.8
5.9
39.13
40.57
mmol/mol
0.96
124
1084
8
32
2.57
1.61
2.1
7.7
—
—
—
0
0
27
170
1.69
1.60
2.8
2.5
172.18
149.81
ug/g
0.08
21
131
21
123
1.80
1.59
6.9
4.2
—
—
—
0
0
5
16
3.18
1.45
2.0
3.4
—
—
—
0
0
41
296
1.50
1.39
2.0
1.7
1.50
1.14
mg/l
0.57
36
236
0
39
0.00
1.35
0.0
14.9
—
—
—
0
0
5
18
2.83
1.29
1.4
1.1
—
—
—
0
0
14
79
1.84
1.21
1.4
1.4
—
—
—
0
0
5
20
2.54
1.16
1.2
1.4
—
—
—
0
0
7
30
2.39
1.13
1.0
1.1
—
—
—
0
0
128
1155
1.37
1.11
3.7
4.0
1.23
1.26
mmol/l
0.18
116
1036
5
22
2.31
1.04
4.0
2.5
—
—
—
0
0
43
332
1.39
1.03
3.6
5.0
2.60
2.78
ug/l
0.07
38
280
7
35
2.04
1.01
1.1
1.3
—
—
—
0
0
7
35
2.04
1.01
2.3
2.3
—
—
—
0
0
14
84
1.72
1.01
2.5
2.5
—
7.02
—
0
5
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
7
37
1.93
0.95
1.1
1.2
—
—
—
0
0
7
37
1.93
0.95
1.1
1.2
—
—
—
0
0
7
37
1.93
0.95
1.1
1.2
—
—
—
0
0
6
28
2.18
0.92
7.5
2.1
—
—
—
0
0
127
1163
1.31
0.88
29.8
16.9
35.88
39.39
%
2.29
62
820
6
30
2.03
0.88
1.0
1.3
—
—
—
0
0
21
146
1.50
0.87
1.7
1.6
—
—
—
0
0
10
57
1.80
0.85
8.6
4.1
—
—
—
0
0
6
31
1.97
0.85
1.0
1.2
0.71
0.84
nmol/l
—
6
26
24
323
0.70
0.83
1.4
1.7
1.50
1.32
mmol/l
0.55
19
266
6
33
1.85
0.80
1.5
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
1.1
—
0.63
—
0
14
0
24
0.00
0.80
0.0
1.1
—
4.17
—
0
14
5
24
2.11
0.75
1.0
5.4
52.50
62.39
%
—
5
24
7
38
1.88
0.74
1.1
1.3
—
—
—
0
0
7
40
1.78
0.72
2.1
1.7
—
—
—
0
0
25
188
1.38
0.71
1.2
1.3
0.97
10.15
u/ml
—
9
73
5
27
1.88
0.69
1.2
1.2
—
—
—
0
0
19
141
1.39
0.59
1.3
1.3
—
—
—
0
0
6
38
1.60
0.55
2.2
2.0
134.67
126.44
g/l
—
6
27
9
62
1.47
0.54
7.3
5.8
7.99
8.37
kpa
—
9
56
6
100
0.59
0.53
1.3
1.6
—
—
—
0
0
25
198
1.30
0.53
1.2
1.3
16.82
37.76
iu/ml
1.57
11
67
130
1229
1.21
0.50
4.3
4.7
5.75
6.01
mmol/l
2.01
118
1100
11
77
1.46
0.46
3.6
2.6
—
—
—
0
0
10
69
1.48
0.45
1.3
1.3
—
27.66
—
0
5
5
31
1.63
0.43
1.4
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
4.1
—
—
—
0
0
38
328
1.20
0.40
4.7
4.1
—
—
—
0
0
7
105
0.65
0.40
1.7
1.6
—
—
—
0
0
16
125
1.31
0.38
5.3
2.9
367.00
233.16
ng/l
0.68
16
112
6
42
1.44
0.36
2.8
4.1
—
—
—
0
0
10
74
1.37
0.33
1.1
1.3
486.47
190.52
u/ml
—
10
69
15
119
1.28
0.33
6.5
3.8
—
—
—
0
0
126
1211
1.13
0.29
4.2
4.4
4.35
4.56
mmol/l
1.28
114
1100
125
1201
1.13
0.29
4.0
4.4
1.45
1.50
mmol/l
0.41
114
1084
10
76
1.33
0.28
1.6
8.4
23.49
24.17
mmol/l
—
10
70
20
169
1.21
0.27
1.3
1.3
—
—
—
0
0
32
360
0.87
0.27
2.7
3.0
176.86
419.01
mg/l
0.42
22
221
9
74
1.23
0.25
1.0
1.2
—
122.98
—
0
27
5
39
1.29
0.23
1.4
1.3
—
—
—
0
0
5
42
1.20
0.21
3.8
16.3
0.74
1.25
mmol/l
—
5
37
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.7
—
—
—
0
0
55
516
1.09
0.18
2.2
2.1
—
—
—
0
0
5
67
0.74
0.17
1.2
1.3
—
—
—
0
0
128
1252
1.08
0.14
4.2
4.9
2.45
2.64
mmol/l
1.40
118
1130
12
105
1.15
0.11
1.0
1.2
—
—
—
0
0
41
391
1.06
0.09
2.7
3.0
6.08
6.85
mmol/l
0.59
33
323
40
382
1.06
0.08
3.6
3.9
20.75
7.59
mg/mmol
0.58
29
230
6
71
0.84
0.08
3.5
14.2
—
—
—
0
0
8
74
1.08
0.07
6.9
3.5
—
—
—
0
0
41
395
1.05
0.06
2.8
3.0
—
—
—
0
0
18
190
0.94
0.04
2.1
3.2
2.24
0.90
ug/l
0.55
13
125
11
117
0.94
0.02
1.5
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
9.88
—
0
5
0
8
0.00
0.00
0.0
2.8
—
7.59
—
0
8
5
50
1.00
0.00
6.4
3.6
3.90
3.96
mmol/l
—
5
44
0
8
0.00
0.00
0.0
15.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
28.28
—
0
5
9
93
0.97
0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
5
52
0.96
0.00
1.4
1.2
—
—
—
0
0
9
91
0.99
0.00
2.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
9
95
0.94
0.00
5.1
3.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PROTMALNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALNAS 2.983 [1.98, 4.5] < 0.001
Birth year 0.999 [0.99, 1.01] 0.849

During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 1180 females with E4_PROTMALNAS died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALNAS 4.251 [2.36, 7.66] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 773 males with E4_PROTMALNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALNAS.

N-year risk Females Males
1 0.239% 1.022%
5 1.836% 5.449%
10 5.126% 13.589%
15 9.269% 24.479%
20 16.303% 39.043%

Relationships between endpoints

↥

Index endpoint: E4_PROTMALNAS – Unspecified protein-energy malnutrition

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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