anal neoplasm: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1009 |
4. Check minimum number of eventsNone |
1009 |
5. Include endpointsNone |
1009 |
6. Filter based on genotype QC (FinnGen only) |
1009 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D12
- Name in latin
- Neoplasma benignum ani
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Anus and anal canal
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Anus and anal canal
- Benign neoplasm: Rectum, anus and anal canal
- Benign neoplasm: Rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6775 | 3595 | 3140 |
| Only index persons | 6211 | 3389 | 2822 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.09 |
| Only index persons | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 65.19 | 64.63 | 65.80 |
| Only index persons | 64.31 | 63.88 | 64.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1009 | 525 | 484 |
| Unadjusted period prevalence (%) | 0.20 | 0.18 | 0.21 |
| Median age at first event (years) | 63.17 | 60.51 | 66.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 895
- Matched controls
- 8945
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.9
ICD-10 Finland
Benign neoplasm: Anus and anal canal
+∞
323.0
895
*
UJF32
NOMESCO Finland
Coloscopy
9.3
200.8
594
1563
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
66.0
117.4
135
24
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
15.6
116.9
201
163
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
8.5
107.0
260
410
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
9.3
82.8
184
241
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
9.9
82.4
176
215
UJH02
NOMESCO Finland
Anoscopy
10.0
60.6
127
146
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
6.0
43.0
127
241
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
4.6
37.9
144
361
UJG02
NOMESCO Finland
Proctoscopy
9.6
36.0
75
84
K62.0
ICD-10 Finland
Anal polyp
20.0
35.2
53
28
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
5.4
29.7
93
187
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.6
28.4
243
1105
JGA73
NOMESCO Finland
Transanal excision of lesion of rectum
80.3
27.9
31
*
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
6.4
27.7
75
126
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
23.9
27.6
39
17
UJF30
NOMESCO Finland
Ileoscopy through colon
3.6
27.2
134
418
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
27.2
336
1848
C05AA08
ATC
fluocortolone; rectal, topical
2.8
26.2
192
792
JHB00
NOMESCO Finland
Hemorrhoidectomy
6.2
26.1
72
124
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
7.0
26.1
66
101
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
25.2
286
1497
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
4.7
25.2
90
209
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
6.6
21.9
57
91
D12.7
ICD-10 Finland
Benign neoplasm: Rectosigmoid junction
12.8
21.0
37
30
JHA00
NOMESCO Finland
Anal or perianal incision
10.1
19.8
39
40
D12
ICD-10 Finland
Benign neoplasm of colon, rectum, anus and anal canal
29.7
19.7
26
9
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
6.3
19.0
51
85
N02BE01
ATC
paracetamol; systemic, rectal
2.2
17.5
767
6531
JHA10
NOMESCO Finland
Biopsy of anal canal
91.8
16.6
18
*
A02BC02
ATC
pantoprazole; systemic
1.8
16.0
595
4660
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
15.9
266
1585
I84.5
ICD-10 Finland
External hemorrhoids without complication
5.0
15.8
51
107
K60.1
ICD-10 Finland
Chronic anal fissure
5.8
15.6
44
79
N02AX02
ATC
tramadol; systemic, rectal
1.8
15.4
395
2726
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
11.1
14.6
27
25
J01DB01
ATC
cefalexin; oral
1.9
13.9
705
5946
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.4
13.2
65
202
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
13.2
210
1217
P01AB01
ATC
metronidazole; oral, rectal
1.7
13.1
344
2360
N03AX16
ATC
pregabalin; oral
1.9
12.8
216
1278
A02BC03
ATC
lansoprazole; oral
1.8
12.7
285
1855
A02BC05
ATC
esomeprazole; systemic
1.7
12.7
361
2527
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
5.5
12.7
37
70
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
4.6
12.6
43
97
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
12.4
213
1265
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
12.0
190
1097
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
12.0
310
2103
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
4.8
11.9
39
84
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
19.2
11.6
17
9
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
11.5
117
559
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
8.5
11.3
24
29
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
10.7
11.3
21
20
A06AC51
ATC
ispaghula, combinations; systemic
3.0
11.0
63
218
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
5.6
10.9
31
57
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
10.8
167
951
K60.3
ICD-10 Finland
Anal fistula
6.4
9.9
25
40
K62.1
ICD-10 Finland
Rectal polyp
7.1
9.8
23
33
UJF92
NOMESCO Finland
Capsular endoscopy
5.4
9.7
28
53
D01
ICPC
Abdominal pain/cramps general
2.3
9.6
93
435
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
9.6
113
577
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
11.6
9.1
16
14
I84
ICD-10 Finland
Hemorrhoids
3.6
9.0
39
111
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
9.0
249
1697
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
8.9
187
1177
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
8.8
80
361
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
8.8
143
827
I84.4
ICD-10 Finland
External hemorrhoids with other complications
5.6
8.6
24
44
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
8.4
384
2949
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
8.3
264
1857
WX110
NOMESCO Finland
Local anesthesy
1.5
8.3
538
4460
R4110
NOMESCO Finland
Physiotherapy
1.6
8.1
235
1611
WX402
NOMESCO Finland
General anaesthesia
1.8
8.1
138
809
WX002
NOMESCO Finland
Sedation and analgesia
1.7
7.9
187
1210
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
3.6
7.9
34
97
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.8
7.9
48
176
N05CF01
ATC
zopiclone; oral
1.6
7.9
291
2121
K59.0
ICD-10 Finland
Constipation
2.5
7.8
60
251
JGA75
NOMESCO Finland
Endoscopic microsurgical excision of lesion of rectum
45.4
7.7
9
*
K92.1
ICD-10 Finland
Melaena
2.5
7.7
57
235
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
7.6
78
377
D16
ICPC
Rectal bleeding
4.6
7.6
25
56
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.5
387
3027
JF2BD
NOMESCO Finland
Extensive colon CT
7.2
7.5
17
24
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
3.4
7.5
34
102
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
7.5
92
480
JFF23
NOMESCO Finland
Transversostomy
5.7
7.4
20
36
A02BC01
ATC
omeprazole; systemic
1.6
7.3
256
1837
JG1CG
NOMESCO Finland
Extensive MRI of rectum
9.5
7.3
14
15
JN4BD
NOMESCO Finland
Extensive body CT
1.9
7.2
105
584
K96
ICPC
Haemorrhoids
3.9
7.1
27
70
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
3.0
7.0
38
130
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
4.1
6.9
25
62
UJD02
NOMESCO Finland
Gastroscopy
2.5
6.9
51
209
N06AX11
ATC
mirtazapine; oral
1.5
6.9
250
1805
D04
ICPC
Rectal/anal pain
4.9
6.9
21
44
JGA96
NOMESCO Finland
Other proctotomy or local operation on rectum
40.3
6.8
8
*
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.7
178
1189
C21.1
ICD-10 Finland
Malignant neoplasm: Anal canal
22.7
6.7
9
*
A02BC04
ATC
rabeprazole; oral
2.2
6.6
68
328
JGB06
NOMESCO Finland
Partial proctectomy with total excision of mesorectum
8.8
6.6
13
15
JG1BG
NOMESCO Finland
MRI of rectum
10.1
6.5
12
12
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.9
6.5
38
137
R03AC02
ATC
salbutamol; inhalant
1.4
6.5
411
3320
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
6.5
145
924
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.4
151
976
J01MA12
ATC
levofloxacin; systemic
1.6
6.4
161
1058
J01AA02
ATC
doxycycline; systemic
1.5
6.4
651
5763
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.6
6.3
42
164
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
6.3
48
201
R35
ICD-10 Finland
Polyuria
2.1
6.3
64
310
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
6.3
204
1432
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.3
6.2
53
234
K57
ICD-10 Finland
Diverticular disease of intestine
3.6
6.2
26
74
H02AB06
ATC
prednisolone; systemic
1.4
6.2
389
3128
Z01.2
ICD-10 Finland
Dental examination
1.5
6.2
290
2201
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.1
357
2828
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
6.1
89
495
J01MA02
ATC
ciprofloxacin; systemic
1.4
6.1
324
2524
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
525
3760
1.82
19.22
5.5
4.7
34.89
35.08
g/l
0.37
489
3470
178
942
2.08
15.95
4.4
4.1
3.78
24.89
ug/l
1.71
152
788
740
6109
1.79
14.64
4.8
4.1
13.22
13.26
mm/h
0.03
680
5592
464
3428
1.65
13.46
3.4
2.8
161.35
137.92
ug/l
0.32
434
3115
595
4705
1.64
12.99
8.8
8.9
4.36
4.19
e9/l
0.76
511
4117
508
3888
1.62
12.45
6.2
5.8
26.67
26.72
%
0.03
477
3612
499
3818
1.61
12.13
5.7
5.6
58.09
58.17
%
0.05
468
3572
325
2239
1.67
12.07
2.7
2.2
3.07
3.14
mg/l
0.19
280
1887
477
3618
1.60
11.97
2.2
2.1
97.44
94.09
pmol/l
0.75
255
1876
616
4969
1.61
11.92
5.3
4.7
6.80
6.75
mmol/l
0.20
583
4665
308
2103
1.67
11.79
4.5
3.8
88.40
87.44
%
0.26
302
2051
157
880
1.93
11.76
2.6
2.1
128.09
140.27
ug/g
0.19
114
697
194
1178
1.80
11.26
2.7
2.5
21.77
22.30
%
0.18
167
1004
752
6426
1.67
11.04
9.5
7.5
78.90
78.88
u/l
0.00
712
6007
213
1351
1.73
10.58
2.6
2.5
11.88
12.60
umol/l
0.77
200
1247
295
2040
1.63
10.55
3.1
2.4
—
—
—
0
0
363
2644
1.58
10.43
3.2
2.4
59.11
57.28
u/l
0.30
327
2437
442
3369
1.55
10.39
2.3
2.2
80.26
78.39
nmol/l
0.74
389
2959
491
3867
1.52
9.72
4.3
4.1
—
—
—
0
0
134
758
1.88
9.70
2.4
2.3
35.20
36.87
u/l
0.12
111
645
196
1250
1.70
9.46
2.6
2.5
2.27
2.30
g/l
0.25
181
1157
531
4274
1.51
9.34
7.4
6.7
1.21
1.21
mmol/l
0.24
443
3585
494
3933
1.50
9.05
6.5
5.8
1.21
1.21
mmol/l
0.26
453
3542
884
8026
1.82
8.92
21.1
15.7
23.40
25.36
mg/l
0.97
762
6475
459
3619
1.49
8.71
11.9
10.5
1.24
1.29
inr
0.62
125
1026
153
932
1.76
8.66
2.5
2.5
8.38
8.63
umol/l
0.05
124
814
545
4456
1.48
8.58
7.2
6.0
11.08
11.48
umol/l
0.43
516
4221
114
646
1.86
8.18
2.0
1.6
—
—
—
0
0
909
8369
1.86
8.12
24.0
18.7
3.97
3.99
mmol/l
1.24
886
8131
907
8357
1.84
7.91
23.5
18.5
139.57
139.64
mmol/l
0.32
886
8131
401
3136
1.46
7.63
3.9
3.3
—
—
—
0
0
56
254
2.27
7.35
1.5
1.4
308.38
288.97
ug/g
0.31
37
155
792
7092
1.54
7.24
21.9
17.0
39.41
39.21
%
0.25
555
4733
380
2969
1.45
7.15
4.0
3.4
2.35
2.35
mmol/l
0.07
326
2575
319
2420
1.46
6.97
3.6
3.2
0.67
0.48
e6/l
0.25
241
1861
811
7335
1.54
6.72
5.4
4.8
1.94
2.12
mu/l
0.48
748
6599
593
5065
1.41
6.58
3.7
3.1
53.06
51.44
u/l
0.10
549
4670
233
1677
1.51
6.57
4.2
4.1
113.14
296.38
ng/l
2.16
190
1372
199
1389
1.54
6.47
3.1
3.0
2.02
2.05
e6/l
0.02
104
775
692
6084
1.44
6.46
4.5
4.0
15.13
14.94
pmol/l
1.04
636
5453
291
2196
1.46
6.45
2.7
2.7
1745.20
6676.00
umol/l
2.29
255
1872
339
2635
1.43
6.40
3.8
3.3
35.10
96.01
e6/l
1.52
263
2062
211
1498
1.52
6.33
1.9
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
58
286
2.09
6.23
2.1
2.7
0.30
0.37
u/ml
0.99
28
165
337
2636
1.42
6.09
2.1
2.1
184.16
243.60
u/l
0.73
318
2472
117
730
1.68
6.04
2.2
2.1
359.52
372.90
nmol/l
0.33
108
660
325
2551
1.40
5.68
2.9
3.1
33.42
32.54
u/l
0.16
296
2426
821
7519
1.49
5.67
6.5
6.2
40.43
40.36
mmol/mol
0.07
758
6896
125
810
1.62
5.57
2.3
2.1
0.21
0.21
g/l
0.08
112
756
205
1487
1.47
5.48
2.8
2.8
1.26
1.12
e6/l
0.13
108
870
723
6494
1.40
5.34
25.0
19.1
13.98
13.80
%
1.76
713
6360
185
1334
1.47
5.07
1.9
1.9
29.36
29.61
s
0.27
178
1281
117
768
1.59
4.94
7.0
6.8
11.50
10.57
mmol/l
0.59
108
727
929
8801
1.70
4.94
30.1
23.2
246.66
245.26
e9/l
0.25
908
8577
190
1385
1.46
4.92
3.4
3.1
0.81
0.82
mmol/l
0.55
175
1287
929
8804
1.69
4.89
30.4
23.3
132.27
133.94
g/l
2.64
916
8658
929
8804
1.69
4.89
30.2
23.1
4.41
4.44
e12/l
0.85
908
8555
120
799
1.57
4.77
6.1
6.3
1.43
1.36
mmol/l
0.20
113
763
817
7545
1.43
4.76
19.4
14.6
75.89
76.52
ml/min/173m2
0.35
705
6256
903
8508
1.58
4.75
13.2
10.8
24.79
25.13
u/l
0.30
874
8174
145
1008
1.51
4.75
3.1
3.8
247.59
250.90
u/l
0.08
138
956
171
1230
1.47
4.74
26.4
28.3
1.48
1.37
inr
0.29
18
153
158
1123
1.48
4.64
5.6
5.4
1.05
1.03
mmol/l
0.42
140
1030
243
1870
1.39
4.64
3.0
2.6
6.01
5.61
e6/l
0.17
210
1655
236
1811
1.40
4.57
1.8
1.6
1.23
1.22
mg/l
0.02
186
1393
149
1053
1.49
4.50
6.1
6.7
5.02
5.08
kpa
0.36
137
1010
149
1054
1.48
4.48
6.0
6.7
12.09
11.93
kpa
0.15
139
1013
226
1731
1.39
4.42
4.1
3.1
2.46
2.46
mmol/l
0.09
192
1522
104
686
1.57
4.32
3.8
3.8
89.92
88.11
ng/l
0.07
83
593
148
1055
1.47
4.28
6.1
6.7
0.35
1.27
mmol/l
1.56
119
825
71
426
1.72
4.27
1.6
2.0
1.63
1.52
g/l
0.40
61
377
841
7850
1.43
4.23
5.2
4.8
6.00
6.01
mmol/l
0.09
772
7045
16
51
3.17
4.22
3.8
3.4
142.56
113.35
nmol/l
0.19
16
51
340
2794
1.33
4.19
2.8
3.0
1710.36
1571.10
ng/l
0.20
304
2400
148
1060
1.46
4.18
1.7
1.8
—
—
—
0
0
147
1056
1.46
4.09
2.7
2.5
1.69
1.82
%
1.01
127
942
178
1327
1.41
4.05
1.3
1.3
31.81
35.99
iu/ml
0.18
49
423
504
4387
1.30
4.02
2.9
2.7
—
—
—
0
0
9
14
6.47
3.98
1.7
1.3
58.78
48.29
umol/l
—
9
14
271
2170
1.34
3.96
1.7
1.6
19.48
20.56
nmol/l
0.55
232
1834
69
423
1.68
3.86
2.8
3.2
4.47
4.41
pmol/l
0.13
61
365
58
339
1.75
3.85
4.9
3.2
122.23
4231.68
u/ml
0.79
53
291
170
1275
1.40
3.73
1.3
1.2
7.33
14.69
u/ml
0.81
52
442
87
571
1.57
3.71
1.8
1.7
—
—
—
0
0
145
1062
1.43
3.64
1.7
1.8
—
—
—
0
0
402
3433
1.28
3.60
4.4
3.9
45.10
53.59
ng/l
0.27
279
2519
42
229
1.87
3.51
2.5
1.7
—
—
—
0
0
66
411
1.65
3.50
3.1
3.6
24.04
24.23
mmol/l
0.18
57
371
21
87
2.44
3.48
1.2
1.2
63.57
53.77
u/l
0.35
14
64
36
187
1.96
3.47
1.3
1.3
—
—
—
0
0
36
187
1.96
3.47
1.3
1.3
—
—
—
0
0
31
154
2.04
3.38
4.2
3.0
3.57
4.54
e9/l
2.04
31
154
32
161
2.02
3.37
4.3
3.2
57.00
59.66
%
0.55
32
161
228
1819
1.33
3.36
1.9
1.7
1044.82
1193.78
nmol/l
1.79
161
1340
28
136
2.09
3.24
1.3
1.3
—
—
—
0
0
74
1082
0.66
3.03
6.5
8.0
—
—
—
0
0
203
1624
1.31
2.92
1.3
1.2
1.09
1.65
u/ml
0.53
37
419
262
2169
1.28
2.90
1.6
1.6
1.34
1.37
mmol/l
0.21
211
1806
185
1462
1.32
2.90
1.6
1.4
2.43
2.55
g/l
0.41
111
868
15
58
2.61
2.88
1.3
1.3
—
—
—
0
0
15
58
2.61
2.88
1.3
1.3
—
—
—
0
0
117
866
1.40
2.79
6.9
7.4
115.93
120.63
g/l
1.84
111
840
125
936
1.38
2.78
4.5
3.5
—
—
—
0
0
9
24
3.77
2.67
1.6
1.2
—
—
—
0
0
849
8077
1.32
2.65
5.3
5.1
2.68
2.67
mmol/l
0.13
792
7328
33
186
1.80
2.55
4.0
2.4
16.50
15.82
%
0.38
21
94
18
82
2.22
2.48
2.3
3.7
56.00
55.78
%
0.01
13
59
45
280
1.63
2.46
1.3
1.2
—
—
—
0
0
14
57
2.48
2.45
2.1
1.2
—
—
—
0
0
14
58
2.43
2.37
2.1
1.3
—
—
—
0
0
22
111
2.00
2.36
1.8
1.5
—
—
—
0
0
203
1672
1.27
2.32
3.7
3.1
0.79
0.79
ug/l
0.01
144
1143
32
185
1.75
2.30
2.4
1.8
—
—
—
0
0
13
53
2.47
2.28
1.5
1.7
6.00
9.25
u/l
—
8
32
22
113
1.97
2.26
1.8
1.5
—
—
—
0
0
22
113
1.97
2.26
1.8
1.5
—
—
—
0
0
51
335
1.55
2.26
2.9
2.5
3.02
3.18
g/l
0.45
41
262
54
360
1.53
2.24
2.8
2.5
3.63
3.78
g/l
0.43
40
258
54
361
1.52
2.21
2.8
2.5
—
—
—
0
0
54
361
1.52
2.21
2.8
2.5
7.47
7.42
g/l
0.06
44
266
12
49
2.47
2.10
1.3
1.3
—
—
—
0
0
12
49
2.47
2.10
1.3
1.3
—
—
—
0
0
50
336
1.51
2.02
3.0
2.5
11.18
10.53
g/l
0.31
43
286
75
549
1.39
1.96
5.0
3.6
1.15
1.92
mmol/l
0.94
65
417
134
1072
1.29
1.94
5.1
4.7
32.91
32.64
%
0.12
105
701
101
778
1.33
1.92
2.8
3.1
284.59
229.99
ng/l
0.54
87
717
21
113
1.88
1.92
1.8
1.5
—
—
—
0
0
793
7563
1.22
1.90
4.1
4.1
1.30
1.27
mmol/l
0.42
717
6783
78
583
1.37
1.82
5.1
3.6
5.10
5.15
kpa
0.19
72
541
818
7837
1.23
1.81
4.6
4.5
1.48
1.46
mmol/l
0.39
748
7085
9
35
2.58
1.80
2.3
1.3
—
—
—
0
0
30
185
1.64
1.76
3.1
3.1
83.25
2013.21
u/ml
0.80
25
174
51
359
1.44
1.68
2.0
1.9
—
—
—
0
0
99
777
1.30
1.68
1.6
1.7
1.47
1.52
%
0.33
83
664
21
119
1.78
1.67
1.7
1.9
32.14
32.70
pg
0.20
21
119
20
113
1.78
1.61
1.8
1.5
—
—
—
0
0
325
2908
1.17
1.57
5.6
5.3
4.54
2.98
ug/l
0.41
293
2565
20
114
1.77
1.57
1.8
1.5
—
—
—
0
0
32
208
1.56
1.55
1.6
1.2
—
—
—
0
0
30
192
1.58
1.55
1.6
1.4
—
—
—
0
0
9
38
2.38
1.45
1.7
1.8
—
—
—
0
0
29
188
1.56
1.44
2.1
1.5
—
—
—
0
0
9
39
2.32
1.43
4.4
4.3
—
—
—
0
0
9
39
2.32
1.43
1.0
1.1
—
—
—
0
0
34
230
1.49
1.40
2.7
1.8
—
—
—
0
0
14
74
1.90
1.39
1.1
1.3
—
—
—
0
0
819
7904
1.19
1.37
4.7
4.6
4.61
4.57
mmol/l
0.44
753
7213
439
4054
1.15
1.35
4.1
3.9
0.00
0.00
estimate
0.00
95
783
28
183
1.54
1.35
1.2
1.3
—
—
—
0
0
13
68
1.92
1.33
1.2
1.1
—
—
—
0
0
6
24
2.51
1.30
1.8
1.2
—
—
—
0
0
14
76
1.85
1.30
1.3
1.1
—
—
—
0
0
43
310
1.40
1.30
2.9
2.9
—
—
—
0
0
34
236
1.46
1.26
1.5
1.6
—
—
—
0
0
28
187
1.51
1.24
3.5
2.2
127.32
127.90
g/l
0.04
22
143
32
220
1.47
1.24
2.4
2.1
93.72
88.29
%
0.64
32
207
5
19
2.64
1.21
1.6
1.9
6.36
7.87
mmol/l
—
5
13
8
37
2.17
1.21
1.6
1.8
—
—
—
0
0
8
37
2.17
1.21
1.6
1.8
—
—
—
0
0
13
71
1.84
1.19
2.2
1.7
—
—
—
0
0
261
2343
1.15
1.19
4.4
4.5
23.28
21.30
%
1.01
130
1180
63
495
1.29
1.12
3.0
1.9
—
—
—
0
0
99
827
1.22
1.06
3.6
3.5
1.55
2.01
mmol/l
0.61
78
662
294
2682
1.14
1.05
3.3
3.1
7.16
7.31
mmol/l
0.22
251
2215
5
22
2.28
1.03
2.4
2.0
—
—
—
0
0
9
48
1.88
1.00
1.0
1.0
—
—
—
0
0
16
99
1.63
1.00
2.5
3.5
—
—
—
0
0
87
723
1.22
0.99
6.2
3.6
1.23
1.23
mmol/l
0.37
75
624
43
328
1.32
0.97
2.2
1.7
—
—
—
0
0
9
50
1.81
0.96
1.1
1.7
—
—
—
0
0
9
50
1.81
0.96
1.1
1.7
—
—
—
0
0
10
54
1.86
0.96
1.4
2.4
—
—
—
0
0
11
186
0.59
0.96
1.4
1.4
—
—
—
0
0
9
51
1.77
0.94
1.2
1.0
281.22
237.76
mg/l
—
9
45
11
62
1.78
0.94
2.4
2.1
13.18
13.21
%
0.03
11
62
65
527
1.25
0.93
1.6
1.5
—
—
—
0
0
431
4059
1.11
0.87
5.4
5.3
0.00
0.00
estimate
0.50
98
780
17
112
1.53
0.85
1.5
1.3
2743.67
1549.25
e6/l
0.38
12
77
27
196
1.39
0.84
1.4
1.4
—
—
—
0
0
8
45
1.78
0.84
2.1
1.7
—
—
—
0
0
296
2738
1.11
0.83
4.3
3.9
8.19
8.75
mg/mmol
0.11
189
1721
21
146
1.45
0.82
2.0
1.7
—
—
—
0
0
8
46
1.74
0.82
2.1
1.7
—
—
—
0
0
55
445
1.25
0.82
2.9
1.8
—
—
—
0
0
97
834
1.18
0.80
3.7
3.4
5.76
5.84
kpa
0.39
91
811
122
1069
1.16
0.80
1.5
1.4
—
—
—
0
0
32
417
0.76
0.79
5.2
3.6
48.07
48.82
%
0.05
32
411
8
48
1.67
0.79
1.5
1.4
1.09
0.98
g/l
—
8
48
32
245
1.32
0.74
1.4
1.5
—
—
—
0
0
211
1929
1.12
0.74
1.8
1.7
430.65
18018448.83
pmol/l
1.55
179
1554
14
92
1.53
0.72
2.1
1.7
—
—
—
0
0
433
4110
1.09
0.71
4.1
3.9
0.00
0.01
estimate
0.80
95
762
38
301
1.27
0.70
4.1
3.7
96.15
74.10
mg/l
0.22
29
249
38
301
1.27
0.70
4.1
3.7
43.99
48.41
mg/l
0.13
29
249
21
152
1.39
0.69
1.3
1.3
192.92
246.31
miu/ml
—
10
67
7
42
1.67
0.68
1.3
1.1
—
—
—
0
0
46
375
1.24
0.67
4.7
4.9
1.48
1.59
%
0.48
41
355
7
43
1.63
0.67
2.0
1.9
505.86
669.57
e6/l
—
7
37
5
28
1.79
0.66
1.2
3.0
—
729.86
—
0
7
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
8
50
1.60
0.61
1.6
1.7
—
—
—
0
0
8
50
1.60
0.61
1.6
1.7
—
—
—
0
0
8
50
1.60
0.61
1.6
1.7
—
—
—
0
0
8
50
1.60
0.61
1.6
1.7
—
—
—
0
0
18
244
0.73
0.61
1.6
1.6
0.49
24.60
iu/ml
—
5
49
26
200
1.31
0.61
1.2
1.2
11.32
10.06
u/ml
—
5
33
27
209
1.30
0.60
3.6
3.0
2.21
1.72
mg/l
1.01
27
189
166
1811
0.90
0.60
3.9
4.3
1.02
1.02
kg/l
0.08
25
254
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
1436.27
—
0
22
0
23
0.00
0.58
0.0
1.0
—
9.33
—
0
23
23
175
1.32
0.58
1.3
1.2
3.62
3.80
mmol/l
0.65
23
161
31
247
1.26
0.57
1.3
1.2
—
—
—
0
0
6
36
1.67
0.56
1.0
1.2
5.42
6.57
mmol/l
—
6
36
41
338
1.22
0.56
1.1
1.0
—
—
—
0
0
275
2585
1.09
0.56
3.5
3.2
1202.86
328.20
mg/l
1.01
179
1642
31
248
1.26
0.55
1.3
1.2
—
—
—
0
0
6
37
1.62
0.55
1.2
1.0
—
—
—
0
0
9
60
1.50
0.54
1.4
1.4
13.11
13.89
u/l
—
9
55
20
151
1.33
0.54
1.4
1.2
26.52
29.12
u/ml
—
5
12
36
296
1.22
0.52
4.2
3.7
—
1.89
—
0
26
9
64
1.41
0.51
1.0
1.1
—
—
—
0
0
23
182
1.27
0.46
1.3
1.3
—
—
—
0
0
16
121
1.33
0.44
2.8
1.6
—
—
—
0
0
7
51
1.37
0.44
1.3
1.2
—
—
—
0
0
110
1004
1.11
0.43
1.5
1.4
—
—
—
0
0
5
31
1.62
0.43
1.8
1.3
3.09
2.73
ug/l
—
5
24
12
87
1.38
0.42
1.2
1.1
—
—
—
0
0
8
57
1.41
0.42
2.1
1.6
—
—
—
0
0
8
57
1.41
0.42
1.4
1.1
—
—
—
0
0
8
57
1.41
0.42
1.4
1.1
—
—
—
0
0
8
57
1.41
0.42
1.4
1.1
—
—
—
0
0
23
185
1.25
0.42
1.1
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
28.63
—
0
10
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
24
196
1.23
0.39
1.3
1.3
—
—
—
0
0
28
233
1.21
0.38
1.9
1.8
—
—
—
0
0
9
67
1.35
0.38
1.4
1.2
14.22
11.20
u/l
—
9
60
10
136
0.73
0.38
1.2
1.1
—
—
—
0
0
13
98
1.33
0.37
1.5
1.3
15572.86
96167.98
e6/l
—
7
56
11
81
1.36
0.36
1.2
2.4
—
—
—
0
0
6
43
1.40
0.35
1.0
1.4
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
6
44
1.37
0.34
1.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
44
1.37
0.34
1.5
1.2
—
—
—
0
0
12
91
1.32
0.33
1.7
1.4
151.17
306.85
pmol/l
2.63
12
71
14
109
1.29
0.33
1.6
1.6
61.11
58.99
%
—
9
74
11
83
1.33
0.32
1.3
1.6
—
—
—
0
0
13
101
1.29
0.31
1.3
1.4
—
—
—
0
0
19
156
1.22
0.31
2.5
1.4
1.24
0.90
nmol/l
0.65
14
128
7
56
1.25
0.29
1.4
1.1
—
—
—
0
0
7
56
1.25
0.29
1.4
1.1
—
—
—
0
0
12
94
1.28
0.28
3.3
2.6
—
—
—
0
0
55
500
1.11
0.27
2.2
1.7
—
—
—
0
0
8
67
1.20
0.26
1.1
1.1
—
70.43
—
0
7
85
791
1.08
0.26
2.2
2.6
7.72
6.73
ug/l
0.25
72
691
9
73
1.23
0.25
1.6
1.1
87.11
96.60
%
—
9
68
9
73
1.23
0.25
1.4
1.6
—
—
—
0
0
22
188
1.17
0.25
1.1
1.1
—
5.74
—
0
20
62
670
0.92
0.23
3.8
2.8
58.41
62.70
ml/min/173m2
0.40
32
283
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
5
41
1.22
0.22
3.6
1.2
—
—
—
0
0
5
42
1.19
0.21
1.6
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
6.1
—
—
—
0
0
8
102
0.78
0.21
1.1
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
14
117
1.20
0.20
2.1
1.6
—
—
—
0
0
10
80
1.25
0.20
1.3
1.4
—
—
—
0
0
10
80
1.25
0.20
1.3
1.4
—
—
—
0
0
10
80
1.25
0.20
1.3
1.4
—
—
—
0
0
10
80
1.25
0.20
1.3
1.4
—
—
—
0
0
6
48
1.25
0.20
2.5
2.4
—
—
—
0
0
20
174
1.15
0.19
1.1
1.1
—
—
—
0
0
321
3137
1.03
0.18
4.6
4.2
—
—
—
0
0
20
225
0.89
0.16
3.7
2.4
89.25
82.66
ug/min
0.04
13
136
74
701
1.06
0.16
3.4
2.7
5.01
4.48
kpa
1.21
69
677
10
83
1.21
0.15
1.3
1.1
—
—
—
0
0
28
255
1.10
0.15
1.5
1.9
—
—
—
0
0
11
129
0.85
0.15
1.8
1.5
—
—
—
0
0
231
2255
1.03
0.14
5.0
4.2
0.00
0.01
estimate
0.88
90
753
50
470
1.07
0.14
1.3
1.2
99.11
135.10
iu/ml
0.32
15
188
14
122
1.15
0.13
1.1
1.1
—
—
—
0
0
55
521
1.06
0.12
2.1
2.2
12.83
12.72
nmol/l
0.03
50
455
41
386
1.06
0.11
2.0
1.9
0.46
2.07
ug/l
1.39
35
338
11
96
1.15
0.10
1.3
1.1
—
—
—
0
0
5
45
1.11
0.10
1.4
1.4
—
—
—
0
0
6
57
1.05
0.08
1.3
1.3
—
—
—
0
0
21
195
1.08
0.08
2.0
1.6
—
—
—
0
0
6
72
0.83
0.07
2.2
1.5
—
—
—
0
0
22
207
1.06
0.06
2.0
1.6
—
—
—
0
0
10
90
1.11
0.05
1.3
1.1
116.20
116.62
%
—
10
82
57
586
0.97
0.05
5.4
6.2
25.09
24.52
mmol/l
0.70
50
554
37
358
1.03
0.04
1.3
1.3
—
—
—
0
0
12
128
0.94
0.02
1.2
1.2
319.29
278.09
u/ml
—
7
67
24
232
1.03
0.02
1.5
1.8
3.11
3.11
mg/l
0.00
18
177
11
117
0.94
0.02
1.8
1.5
—
—
—
0
0
15
143
1.05
0.01
1.5
1.5
—
—
—
0
0
14
146
0.96
0.00
1.6
1.5
—
—
—
0
0
19
184
1.03
0.00
2.4
1.6
4.67
4.79
iu/l
—
6
53
11
106
1.04
0.00
1.5
1.2
2.67
7.67
u/ml
—
6
45
11
115
0.96
0.00
1.8
1.6
—
—
—
0
0
11
107
1.03
0.00
1.1
1.1
—
—
—
0
0
25
253
0.99
0.00
1.6
1.4
—
—
—
0
0
13
135
0.96
0.00
1.1
1.2
—
—
—
0
0
16
157
1.02
0.00
2.4
2.0
71.60
59.29
%
2.26
16
157
12
122
0.98
0.00
2.2
2.5
25.40
28.75
mg/l
—
5
31
22
221
0.99
0.00
1.9
1.7
23765.38
13665.74
e6/l
0.23
13
158
11
109
1.01
0.00
2.9
1.8
855.80
1039.39
u/l
—
5
37
11
110
1.00
0.00
6.3
6.1
9.43
12.49
mg/l
1.36
11
101
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
8
87
0.92
0.00
1.9
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
8
83
0.96
0.00
1.6
1.6
—
—
—
0
0
7
73
0.96
0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
0.00
1.0
1.3
—
—
—
0
0
9
89
1.01
0.00
3.1
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
2.8
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
0.00
3.4
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
—
—
0
0
7
69
1.01
0.00
1.7
1.5
—
—
—
0
0
6
67
0.89
0.00
1.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.6
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_ANUS_ANAL_CANAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ANUS_ANAL_CANAL | 1.11 [0.99, 1.24] | 0.066 |
| Birth year | 0.998 [0.99, 1.01] | 0.643 |
During the follow-up period (1.1.1998 — 31.12.2019), 811 out of 3244 females with CD2_BENIGN_ANUS_ANAL_CANAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ANUS_ANAL_CANAL | 1.233 [1.1, 1.39] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 997 out of 2848 males with CD2_BENIGN_ANUS_ANAL_CANAL died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_ANUS_ANAL_CANAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | 0.274% |
| 5 | 0.735% | 1.418% |
| 10 | 1.683% | 3.814% |
| 15 | 3.423% | 7.36% |
| 20 | 6.062% | 12.725% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_ANUS_ANAL_CANAL – Benign neoplasm: Anus and anal canal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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